The continued evolution of the L2 cephalosporinase in Stenotrophomonas maltophilia: a key driver of beta-lactam resistance.

PMID: 398045742025

Key Findings

The study identifies and characterizes L2 beta-lactamase variants in Stenotrophomonas maltophilia, highlighting the role of Phe72 in enzymatic activity and resistance to beta-lactam antibiotics, particularly ceftazidime.

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1gene entry

8mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaL2	1	beta-lactamase	Ceftazidime	Stenotrophomonas maltophilia Escherichia coli	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaL2	I72F	-	enhanced resistance	Escherichia coli, Stenotrophomonas maltophilia	Ceftazidime\|Cephalexin\|AztreonamCephalexin\|Cefazolin\|Cefoxitin\|Ceftazidime\|Ceftriaxone\|Cefepime\|Aztreonam\|Meropenem\|Imipenem	Reslit	-
blaL2	F72I	-	reduced resistance	Escherichia coli, Stenotrophomonas maltophilia	Cephalexin\|Cefazolin\|Cefoxitin\|Ceftazidime\|Ceftriaxone\|Cefepime\|Aztreonam\|Meropenem\|ImipenemCeftazidime\|Cephalexin\|Aztreonam	Reslit	-

Browse Papers

The continued evolution of the L2 cephalosporinase in Stenotrophomonas maltophilia: a key driver of beta-lactam resistance.

AMR Genes

AMR Mutations