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An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids.

PMID: 398392182024

Key Findings

gyrA_S83F mutation associated with reduced susceptibility to fluoroquinolones

4gene entries

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
aph(3'')-Ib	1	aminoglycoside phosphotransferase	Aminoglycoside	Salmonella enterica subsp. enterica serovar Typhi	Reslit	-
dfrA14	1	dihydrofolate reductase	Trimethoprim	Salmonella enterica subsp. enterica serovar Typhi	Reslit	-
sul2	1	sulfonamide resistance protein	Sulfonamide	Salmonella enterica subsp. enterica serovar Typhi	Reslit	-
tetB	1	tetracycline efflux pump	Tetracycline	Salmonella enterica subsp. enterica serovar Typhi	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	S83F	-	-	Salmonella Typhi	Fluoroquinolones	Reslit	-