Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen Haemophilus influenzae.

PMID: 409809202025

Key Findings

The study identifies ftsI and ompP2 mutations as primary drivers of beta-lactam resistance in Haemophilus influenzae, with specific amino acid substitutions in ftsI and structural rearrangements in ompP2 contributing to increased MICs for ampicillin, cefotaxime, and ceftriaxone.

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1gene entry

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
ompp2	1	outer membrane protein P2	AmpicillinCefotaximeCeftriaxone	Haemophilus influenzae	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ftsI	T322I	-	-	Haemophilus influenzae	Ampicillin\|Cefotaxime\|Ceftriaxone	Reslit	-

Browse Papers

Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen Haemophilus influenzae.

AMR Genes

AMR Mutations