Comprehensive analysis of mutations associated with rifampicin- and isoniazid-resistant tuberculosis in a high-burden setting.

PMID: 409906962025

Key Findings

borderline mutation

0gene entries

25mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	F433F	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	D435Y	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	H445S	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
katG	S315I	-	-	Mycobacterium tuberculosis	Isoniazid	Reslit	-
rpoB	Q432K	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	P439L	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	H445D	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
katG	S315N	-	-	Mycobacterium tuberculosis	Isoniazid	Reslit	-
rpoB	Q432R	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	S441S	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	S450L	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
katG	S315G	-	-	Mycobacterium tuberculosis	Isoniazid	Reslit	-
rpoB	Q432P	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	H445C	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	S450W	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
katG	A379V	-	-	Mycobacterium tuberculosis	Isoniazid	Reslit	-
rpoB	H445N	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	Q432H	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	H445L	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	L452P	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
katG	A379T	-	-	Mycobacterium tuberculosis	Isoniazid	Reslit	-
rpoB	L430P	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	Q432Q	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	H445R	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
katG	S315T	-	-	Mycobacterium tuberculosis	Isoniazid	Reslit	-