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Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity.

PMID: 412984582025

Key Findings

The V612F mutation in AcrB leads to a conformational shift favoring the T state, affecting substrate binding and efflux.

0gene entries

7mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
acrB	V612F	-	increased resistance to tetracycline, fluoroquinolone, and linezolid, but reduced resistance to macrolides, increases resistance to linezolid, chloramphenicol, tetracycline, and fluoroquinolones, but decreases resistance to macrolides	Klebsiella pneumoniae, E. coli, Burkholderia pseudomallei	Tetracycline\|FluoroquinolonesLinezolid\|Chloramphenicol\|Tetracycline\|Fluoroquinolones	Reslit	-
oqxB	V612W	-	altered substrate binding and efflux	Klebsiella pneumoniae, Burkholderia pseudomallei, E. coli	Tetracycline\|Fluoroquinolones	Reslit	-