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Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.

PMID: 78405921994

Key Findings

Double mutation at Ser83 and Asp87 enhances ciprofloxacin resistance

0gene entries

11mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	S83L	-	multiple resistance variants	Escherichia coli	Ciprofloxacin\|Nalidixic acidFluoroquinolones	ReslitCard Database	-
gyrA	A84V	-	DNA gyrase subunit A GyrA, Target modification	Escherichia coli	QUINOLONENalidixic acid,Ciprofloxacin	Reference Gene CatalogResFinder Database	-
gyrA	D87N	-	DNA gyrase subunit A GyrA, multiple resistance variants	Escherichia coli	QUINOLONEFluoroquinolones	Reference Gene CatalogCard Database	-
gyrA	D87Y	-	DNA gyrase subunit A GyrA, multiple resistance variants	Escherichia coli	QUINOLONEFluoroquinolones	Reference Gene CatalogCard Database	-
gyrB	K447E	-	DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB	Escherichia coli	NALIDIXIC ACID	Reference Gene Catalog	-
gyrA	A84P	-	Target modification	Escherichia coli	Nalidixic acid,Ciprofloxacin	ResFinder Database	-