Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
global regulator
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G103S | - | single resistance variant | Escherichia coli, Escherichia spp. | nalidixic acidciprofloxacinampicillin+10 more | Card DatabaseReslit | Confirmed |
| T39I | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| M74I | - | - | E. coli | tetracycline | Reslit | Candidate |
| C108Y | - | loss-of-function | Escherichia coli | ampicillintetracycline | Reslit | Candidate |
| L46P | - | loss-of-function | Escherichia coli | ampicillintetracycline | Reslit | Candidate |
| R296H | - | - | Escherichia coli | phenicols | Reslit | Candidate |
| G22D | - | - | Escherichia coli | ampicillin | Reslit | Candidate |
| G28R | - | - | Escherichia coli | fluoroquinolones | Reslit | Candidate |
| M1V | - | - | - | carbapenemscolistin | Reslit | Candidate |
| V66A | - | - | Escherichia coli | ceftriaxone | Reslit | Candidate |
| R62C | - | - | Escherichia coli | gatifloxacin | Reslit | Candidate |
| S83L | - | Escherichia coli | ciprofloxacin | Reslit | Candidate | |
| L71P | - | - | - | tigecycline | Reslit | Candidate |
| K44Y | - | - | - | tigecycline | Reslit | Candidate |
| A53E | - | - | - | tigecycline | Reslit | Candidate |
| M1G | - | - | - | tigecycline | Reslit | Candidate |
| Y137H | - | single resistance variant | Escherichia spp., Escherichia coli | tigecyclineciprofloxacinmultiple antibiotics | Card DatabaseReslit | Confirmed |
| V84E | - | - | E. coli, Escherichia coli | phenicolsciprofloxacin | Reslit | Candidate |
| L109F | - | - | E. coli | phenicols | Reslit | Candidate |
| V11I | - | mutations that relieve transcriptional repression by MarR consequently upregulate the expression of the efflux pump and increase antibiotic resistance | Shewanella oneidensis | ciprofloxacin | Reslit | Candidate |
| S3N | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | fluoroquinolonesphenicolsrifampicin+4 more | Card DatabaseReference Gene CatalogReslit | Confirmed |
| L78R | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| E136D | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| 22fs | - | loss of repressor activity | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| G81C | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| G81D | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| D87G | - | - | Escherichia coli | ciprofloxacinlevofloxacin | Reslit | Candidate |
| R27P | - | - | Escherichia coli | levofloxacin | Reslit | Candidate |
| L33R | - | - | Escherichia coli | levofloxacin | Reslit | Candidate |
| Q42E | - | - | Escherichia coli | levofloxacin | Reslit | Candidate |
| G69E | - | Escherichia coli | levofloxacinphenicolsdelafloxacin+1 more | Reslit | Supported | |
| T102S | - | - | Escherichia coli | levofloxacin | Reslit | Candidate |
| L123S | - | - | Escherichia coli | levofloxacin | Reslit | Candidate |
| L115P | - | - | - | ciprofloxacin | Reslit | Candidate |
| R73S | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | phenicolsmultiple antibioticsampicillin+3 more | Card DatabaseReference Gene CatalogReslit | Confirmed |
| G104C | - | - | E. coli | ciprofloxacin | Reslit | Candidate |
| D67Y | - | - | E. coli | ciprofloxacin | Reslit | Candidate |
| W63R | - | - | E. coli | ciprofloxacin | Reslit | Candidate |
| R94H | single resistance variant, transcriptional regulator MarR | E. coli, Escherichia coli | ciprofloxacinmultiple antibioticsampicillin+5 more | Card DatabaseReference Gene CatalogReslit | Confirmed | |
| V41M | - | - | Escherichia coli | benzalkonium chloridephenicolstriclosan | Reslit | Candidate |
| R152C | - | - | Escherichia coli | benzalkonium chloridephenicolstriclosan | Reslit | Candidate |
| L75R | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| D67N | - | - | Escherichia coli | fluoroquinolones | Reslit | Candidate |
| V66F | - | - | Escherichia coli | ampicillin | Reslit | Candidate |
| R94S | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillinphenicols+3 more | Card DatabaseReference Gene Catalog | Confirmed |
| V96E | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillinphenicols+3 more | Card DatabaseReference Gene Catalog | Confirmed |
| I49S | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillinphenicols+3 more | Card DatabaseReference Gene Catalog | Confirmed |
| R77C | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillinphenicols+3 more | Card DatabaseReference Gene Catalog | Confirmed |
| V45E | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillinphenicols+3 more | Card DatabaseReference Gene Catalog | Confirmed |
| E31* | - | nonsense mutation, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillinphenicols+3 more | Card DatabaseReference Gene Catalog | Confirmed |
| R73C | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillinphenicols+3 more | Card DatabaseReference Gene Catalog | Confirmed |
| A70T | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillinphenicols+3 more | Card DatabaseReference Gene Catalog | Confirmed |
| L78M | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillinphenicols+3 more | Card DatabaseReference Gene Catalog | Confirmed |
| R77L | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillinphenicols+3 more | Card DatabaseReference Gene Catalog | Confirmed |
| R58L | - | single resistance variant | Escherichia coli | multiple antibiotics | Card Database | Established |
| T72P | - | - | delafloxacin | Reslit | Candidate | |
| - | - | Escherichia coli | norfloxacin | Reslit | Candidate | |
| - | - | Salmonella enterica | ciprofloxacin | Reslit | Candidate | |
| G69R | - | - | delafloxacin | Reslit | Candidate | |
| R86S | - | - | ciprofloxacin | Reslit | Candidate | |
| G106D | - | Escherichia coli | tetracyclinephenicols | Reslit | Candidate | |
| M74T | - | E. coli | tetracycline | Reslit | Candidate | |
| L87W | - | - | ciprofloxacin | Reslit | Candidate | |
| - | - | Escherichia coli | phenicols | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| mar | Reslit | 1 | Tetracycline, Nalidixic acid, Ciprofloxacin | Escherichia coli O157:H7 | - | 2004 | - | - |
| mar R | Reslit | 1 | Multiple antibiotics | Escherichia coli, Klebsiella pneumoniae | North America | 2023 | ERP146025 | - |
Intrinsic mechanism decreases susceptibility of Escherichia coli O157:H7 to multiple antibiotics.
Research Article
Chloramphenicol-resistant mutants of Escherichia coli O157:H7 showed increased resistance to tetracycline, nalidixic acid, and ciprofloxacin. Mutation in the mar operon was linked to decreased susceptibility.
Impact of immigration on antibiotic resistance genes in activated sludge: A study using digital droplet PCR and amplicon sequencing
Research Article
The study reveals that immigration of influent wastewater into activated sludge leads to an increase in the abundance of over 70% of the quantified antibiotic resistance genes (ARGs). Specific ARGs such as blaTEM, blaMOX, qnrS, qnrB, mphE, dfrA, tetO, tetQ, tetE, marR, msrD, robA, qacL, blaOXA, and ereA were found to increase in abundance with immigration, indicating the impact of influent immigration on the persistence of AMR in wastewater treatment plants.
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