Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
pncA pyrazinamidase | T100I | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Supported |
| T100P | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
| T114A | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
| T114fs | - | frameshift mutation | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
pncA Pyrazinamidase/nicotinamidase | T114M | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
pncA pyrazinamidase | T114P | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
| T135I | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
| T135N | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
pncA pyrazinamidase | T135P | loss of PZAse activity, loss of activity, decreased ability to hydrolyze PZA, single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed | |
| T135S | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established |
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