Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
rpoB RNA polymerase beta subunit | D435A | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder DatabaseReslit | Confirmed |
rpoB RNA polymerase beta subunit | D435E | - | single resistance variant, multiple resistance variants | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder DatabaseReslit | Confirmed |
rpoB RNA polymerase beta subunit | D435F | - | single resistance variant | Mycobacterium tuberculosis, Mycobacterium bovis | rifampicin | Card DatabaseResFinder DatabaseReslit | Confirmed |
rpoB RNA-polymerase beta-subunit | D435G | single resistance variant | Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium bovis | rifampicincapreomycinrifabutin | Card DatabaseResFinder DatabaseReslit | Confirmed | |
rpoB RNA polymerase beta subunit | D435H | - | single resistance variant | Mycobacterium bovis, Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder DatabaseReslit | Confirmed |
| D435K | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established | |
| D435L | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established | |
rpoB RNA polymerase beta subunit | D435N | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder DatabaseReslit | Confirmed |
| D435T | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established | |
rpoB RNA polymerase beta subunit | D435V | substitutes the negatively charged aspartate with a bulkier nonpolar valine residue causing steric hindrance within the rifampicin-binding pocket, increased IC 50 of both rifamycins, single resistance variant, multiple resistance variants | Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium bovis, Escherichia coli | rifampicincapreomycinrifabutin | Card DatabaseResFinder DatabaseReslit | Confirmed |
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