Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	D435Var	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB RNA polymerase beta subunit	D435X	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA-polymerase beta-subunit	D435Y	G1305T G1304T G1303T	single resistance variant, multiple resistance variants	Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	D441A	-	loss of interactions with drug except Gly438, Phe439 and Arg465	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	D441C	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	D441F	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	D441N	-	-	Mycobacterium tuberculosis, Mycobacterium leprae	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	D441V	-	-	Mycobacterium tuberculosis, Mycobacterium leprae	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	D441Y	GAT->TAT	-	Mycobacterium tuberculosis, Mycobacterium leprae	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	D449N	-	-	Staphylococcus aureus	phenicolslinezolidretapamulin+1 more	Reslit	Candidate