Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
bioC O-methyltransferase	D75A	-	The D75A mutation disrupts SAM binding and reduces enzymatic activity, indicating a critical role in BioC function.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bioC O-methyltransferase	E50A	-	The E50A mutation disrupts SAM binding and reduces enzymatic activity, indicating a critical role in BioC function.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bioC O-methyltransferase	K194A	-	The K194A mutation affects the interaction with the ACP carrier, reducing enzymatic activity.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bioC O-methyltransferase	K201A	-	The K201A mutation affects the interaction with the ACP carrier, reducing enzymatic activity.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bioC O-methyltransferase	K215A	-	The K215A mutation affects the interaction with the ACP carrier, reducing enzymatic activity.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bioC O-methyltransferase	Q116A	-	The Q116A mutation disrupts the neutralization of the malonyl group, affecting substrate binding and enzymatic activity.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bioC O-methyltransferase	Q26A	-	The Q26A mutation disrupts the neutralization of the malonyl group, affecting substrate binding and enzymatic activity.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bioC O-methyltransferase	R212A	-	The R212A mutation affects the interaction with the ACP carrier, reducing enzymatic activity.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bioC O-methyltransferase	W117A	-	The W117A mutation disrupts SAM binding and reduces enzymatic activity, indicating a critical role in BioC function.	Acinetobacter baumannii, Klebsiella pneumoniae	polymyxins	Reslit	Candidate
bla CMY-16 beta-lactamase	N346H	-	reduced inhibition efficacy of avibactam	Klebsiella pneumoniae	aztreonamavibactam	Reslit	Candidate