Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB DNA-directed RNA polymerase subunit beta	H442R	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H442Y	C1324T	-	-	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H445A	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H445C	CAC > TGC	single resistance variant, multiple resistance variants	Mycobacterium tuberculosis	rifampicin	Card DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H445D	C1333G CTG->GAT C1335G	replaces a neutral histidine with a negatively charged residue, weakening hydrogen bonding and destabilizing drug interactions, multiple resistance variants, single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	rifampicinrifabutin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB	H445E	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB RNA polymerase subunit beta	H445F	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase subunit beta	H445G	-	single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H445L	C1333T	single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H445N	C1335T C1333A	single resistance variant	Mycobacterium tuberculosis, Staphylococcus aureus	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed