Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB RNA polymerase beta subunit	H445P	-	single resistance variant, multiple resistance variants	Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H445Q	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H445R	CAT->CGT CAC->CGT C1333A CTG->AGG	single resistance variant	Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium bovis	rifampicincapreomycinrifabutin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase subunit beta	H445S	-	single resistance variant, multiple resistance variants	Mycobacterium tuberculosis	rifampicin	Card DatabaseReslit	Confirmed
rpoB DNA-directed RNA polymerase beta subunit	H445T	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card DatabaseReslit	Confirmed
rpoB	H445Var	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB RNA polymerase beta subunit	H445X	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB Bacterial RNA polymerase switch region	H445Y	CAT->TAT CAC->TAT GTT->TAT C1333T CTG->TAT C1335T	disrupts an intermolecular hydrogen bond between histidine and rifampicin and introduces an aromatic ring that sterically interferes with rifampicin binding, The rpoB H445Y mutation in Mtb is associated with an increased transcription elongation rate, single resistance variant, multiple resistance variants	Mycobacterium tuberculosis, Mycobacterium smegmatis, Escherichia coli, Mycobacterium bovis	rifampicincapreomycinrifabutin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H447Y	-	-	-	rifamycins	Reslit	Candidate
rpoB RNA polymerase beta subunit	H450Y	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate