Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB beta-subunit of RNA polymerase	H513L	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H513R	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H516L	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H516V	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H516Y	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	H517N	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H521R	A1562G	-	Pseudomonas aeruginosa, P. fulva, P. stutzeri, P. mendocina, P. protegens, P. fluorescens, P. putida	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H526A	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H526C	CAC->TGC	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	H526D	CAC-GAC CAC->GAC C1578T C1576A	disrupted the intermolecular hydrogen bond between wild-type His526 and the RIF molecule	Mycobacterium tuberculosis, Escherichia coli, Mycobacterium smegmatis, Rhodococcus equi, Mycobacterium gastri	rifampicinrifabutinvancomycin	Reslit	Supported