Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB RNA polymerase beta subunit	H526E	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase	H526F	-	-	Mycobacterium tuberculosis, Mycobacterium smegmatis	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	H526G	-	disrupted the intermolecular hydrogen bond between wild-type His526 and the RIF molecule	Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	H526L	CAC-CTC CAC->CTG A1578T	disrupted the intermolecular hydrogen bond between wild-type His526 and the RIF molecule, DNA-directed RNA polymerase subunit beta RpoB	Mycobacterium tuberculosis, Escherichia coli, Mycobacterium smegmatis, Salmonella enterica, Shigella sonnei	rifampicin	Reference Gene CatalogReslit	Confirmed
rpoB RNA polymerase beta subunit	H526N	CAC-AAC CAC->AAC	-	Mycobacterium tuberculosis, Escherichia coli, Mycobacterium smegmatis, Rhodococcus equi, Mycoplasma faucium	rifampicinrifabutin	Reslit	Supported
rpoB RNA polymerase beta subunit	H526P	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	H526Q	-	-	Mycobacterium tuberculosis, Mycobacterium smegmatis	rifampicinrifabutin	Reslit	Supported
rpoB RNA polymerase beta subunit	H526R	CAC-CGC CAC->CGC	had hydrogen bond contact with and electrostatic attraction to the RIF molecule	Mycobacterium tuberculosis, Mycobacterium smegmatis, Rhodococcus equi	rifampicinrifabutin	Reslit	Supported
rpoB RNA polymerase beta subunit	H526S	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB β subunit of the RNA polymerase	H526T	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported