Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB β-subunit of the DNA-dependent RNA polymerase	H526Y	CAC-TAC CAC->TAC C1577T CTG->TAC C1578T C1576T	Target modification, single resistance variant, DNA-directed RNA polymerase subunit beta RpoB	Mycobacterium tuberculosis, Escherichia coli, Mycobacterium smegmatis, Rhodococcus equi, Photorhabdus luminescens, M. tuberculosis, Shigella sonnei	rifampicinrifabutinrifapentine+1 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H529Y	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB β-subunit of RNA polymerase	H531C	-	-	Pseudomonas fluorescens, Pseudomonas aeruginosa	rifampicin	Reslit	Candidate
rpoB RNA polymerase β-chain	H531L	A1592T	-	Pseudomonas aeruginosa, Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB	H531R	A1592G	-	Mycobacterium tuberculosis, Pseudomonas aeruginosa	rifampicin	Reslit	Candidate
rpoB RNA polymerase β-chain	H531Y	C1591T	-	Pseudomonas aeruginosa, Pseudomonas fluorescens, Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	H540C	-	-	Helicobacter pylori	rifampicin	Reslit	Candidate
rpoB Beta-subunit of RNA polymerase	H540N	-	Target modification, single resistance variant	Helicobacter pylori	rifampicinrifabutin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H540Y	C1620T	single resistance variant	Bartonella bacilliformis, Helicobacter pylori	rifampicinrifabutin	Card DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H541Y	-	-	Legionella pneumophila	rifampicin	Reslit	Candidate