Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpsL ribosomal protein S12	K43R	A129G A128G A127G AAG->CGG C129T C127T	resistance, changed the tertiary structure of the 16S rRNA leading to decreased affinity to SM and high-level resistance, confers resistance to streptomycin, Target modification, single resistance variant, 30S ribosomal protein S12	Mycobacterium tuberculosis, Campylobacter jejuni, Mycobacterium bovis, Mycobacterium smegmatis, Francisella novicida, Francisella tularensis, Erwinia amylovora, E. amylovora, Neisseria meningitidis, Yersinia pestis, Campylobacter coli, Campylobacter spp., Agrobacterium fabrum, Haemophilus parasuis, Bifidobacterium bifidum, Escherichia coli	streptomycinaminoglycosideskanamycin	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
rpsL protein S12 of the 30S ribosomal subunit	K43T	-	30S ribosomal protein S12	Mycobacterium tuberculosis, Escherichia coli, Mycobacterium smegmatis	streptomycinamikacingentamicin+3 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
rpsL ribosomal protein S12	K47R	-	-	-	streptomycin	Reslit	Candidate
rpsL	K51N	-	-	Mycobacterium tuberculosis	streptomycin	ResFinder Database	Established
rpsL S12 ribosomal protein	K56I	-	-	Streptococcus pneumoniae	streptomycin	Reslit	Candidate
rpsL S12 ribosomal protein	K56N	-	-	Bacillus pumilus, Geobacillus kaustophilus	streptomycin	Reslit	Candidate
rpsL ribosomal protein S12	K56R	-	-	Lactobacillus gallinarum, Streptococcus pneumoniae	streptomycin	Reslit	Candidate
rpsL S12 ribosomal protein	K56T	-	-	Streptococcus pneumoniae	streptomycin	Reslit	Candidate
rpsL ribosomal protein S12	K83R	AAG->CGG	-	-	gentamicinstreptomycin	Reslit	Supported
rpsL ribosomal protein S12	K87R	-	-	Mycobacterium tuberculosis	streptomycin	Reslit	Candidate