Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
sgm aminoglycoside resistance methyltransferase	D182A	-	abrogated Sgm activity	E. coli	aminoglycosides	Reslit	Candidate
sgm aminoglycoside resistance methyltransferase	E205A	-	abolished MT activity	E. coli	aminoglycosides	Reslit	Candidate
sgm aminoglycoside resistance methyltransferase	E267A	-	abolished MT activity	E. coli	aminoglycosides	Reslit	Candidate
sgm aminoglycoside resistance methyltransferase	G135A	-	abrogated Sgm activity	E. coli	aminoglycosides	Reslit	Candidate
sgm aminoglycoside resistance methyltransferase	K199A	-	abolished MT activity	E. coli	aminoglycosides	Reslit	Candidate
sgm aminoglycoside resistance methyltransferase	N179A	-	wild-type phenotype	E. coli	aminoglycosides	Reslit	Candidate
sgm aminoglycoside resistance methyltransferase	R236A	-	abolished MT activity	E. coli	aminoglycosides	Reslit	Candidate
sigA primary sigma factor	G336C	-	reduces susceptibility to vancomycin and fosfomycin by altering promoter recognition.	Bacillus subtilis	vancomycinfosfomycin	Reslit	Candidate
sigA sigma factor subunit of RNA polymerase	R515H	-	disrupting, knocking out, or mutating the gene causes SUSCEPTIBILITY	Mycobacterium smegmatis	spectinomycintetracyclineclarithromycin	Reslit	Candidate
sigE Extracytoplasmic function sigma factor	V166L	-	The V166L substitution falls within the SigE σ 2 /σ 4 linker, influencing transcription initiation.	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate