Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
grlA DNA gyrase subunit A	E84G	A253G	Target modification	Staphylococcus aureus	ciprofloxacinmoxifloxacinfluoroquinolones+1 more	ResFinder DatabaseReslit	Confirmed
grlA topoisomerase IV subunit A	E84K	-	mutations in grlA (Ser80→Phe or Tyr) were most commonly selected with trovafloxacin, ciprofloxacin, levofloxacin, or pefloxacin, mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones, Target modification	Staphylococcus aureus	ciprofloxacinlevofloxacinsparfloxacin+3 more	ResFinder DatabaseReslit	Confirmed
grlA topoisomerase IV A subunit	E84L	-	-	-	fluoroquinolones	Reslit	Candidate
grlA	E84V	-	Target modification	Staphylococcus aureus	ciprofloxacin	ResFinder Database	Established
grlA topoisomerase IV	E85K	-	disrupts the water-metal ion bridge	Bacillus anthracis	ciprofloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	G78C	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacinlevofloxacinmoxifloxacin	Reslit	Candidate
grlA DNA topoisomerase IV A	G80R	-	-	Staphylococcus hominis	ciprofloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	H103Y	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacinlevofloxacinmoxifloxacin	Reslit	Candidate
grlA DNA gyrase subunit A	I45M	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones, Target modification	Staphylococcus aureus	ciprofloxacinlevofloxacinmoxifloxacin	ResFinder DatabaseReslit	Confirmed
grlA topoisomerase IV subunit A	K23N	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacinlevofloxacinmoxifloxacin	Reslit	Candidate