Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
grlA topoisomerase IV subunit A	N327K	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacinlevofloxacinmoxifloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	P157L	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacinlevofloxacinmoxifloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	P451L	-	-	-	ciprofloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	P451S	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacinlevofloxacinmoxifloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	R43C	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacinlevofloxacinmoxifloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	R85Q	-	-	-	ciprofloxacin	Reslit	Candidate
grlA DNA topoisomerase IV subunit A	S143P	-	-	Staphylococcus aureus	ciprofloxacin	Reslit	Candidate
grlA DNA gyrase subunit A	S144P	-	-	-	ciprofloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	S52R	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacinlevofloxacinmoxifloxacin	Reslit	Candidate
grlA	S80F	AGT -> TTC G240T A239G C241T	reduced the potency of ciprofloxacin, mutations in grlA (Ser80→Phe or Tyr) were most commonly selected with trovafloxacin, ciprofloxacin, levofloxacin, or pefloxacin, resistance, confers resistance to fluoroquinolones, mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones, Target modification	Staphylococcus aureus, Streptococcus pneumoniae, S. epidermidis, S. haemolyticus, S. arlettae, S. simulans, S. saprophyticus, S. borealis, S. sciuri, S. hominis, S. pasteuri, S. hyicus	quinolonesciprofloxacinfluoroquinolones+10 more	ResFinder DatabaseReslit	Confirmed