Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
grlA topoisomerase IV subunit A | V41G | - | mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones, Target modification | Staphylococcus aureus | ciprofloxacinlevofloxacinmoxifloxacin | ResFinder DatabaseReslit | Confirmed |
grlA DNA gyrase subunit A | V694M | - | - | Staphylococcus aureus | fluoroquinolones | Reslit | Candidate |
grlA DNA gyrase subunit A | V82L | - | - | Staphylococcus aureus | levofloxacin | Reslit | Candidate |
grlA topoisomerase IV A subunit | V96A | - | resistance to quinolones and quinazolinediones without disrupting the water-metal ion bridge | Bacillus anthracis | ciprofloxacin | Reslit | Candidate |
grlA DNA topoisomerase IV subunit A | Y80H | - | - | Staphylococcus aureus | levofloxacin | Reslit | Candidate |
| Y83N | - | Target modification | Staphylococcus aureus | ciprofloxacin | ResFinder Database | Established | |
| D432G | - | Target modification | Staphylococcus aureus | ciprofloxacin | ResFinder Database | Established | |
| D432H | - | Target modification | Staphylococcus aureus | ciprofloxacin | ResFinder Database | Established | |
| D432N | - | Target modification | Staphylococcus aureus | ciprofloxacin | ResFinder Database | Established | |
| D432V | - | Target modification | Staphylococcus aureus | ciprofloxacin | ResFinder Database | Established |
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