Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
grlA DNA gyrase subunit A	S80G	-	-	Staphylococcus coagulans	ciprofloxacinmoxifloxacin	Reslit	Candidate
grlA topoisomerase IV A subunit	S80I	TCA->ATA	DNA topoisomerase GrlA	Staphylococcus pseudintermedius, Staphylococcus coagulans, Staphylococcus aureus, Staphylococcus intermedius	enrofloxacinciprofloxacinmoxifloxacin+2 more	Reference Gene CatalogReslit	Confirmed
grlA DNA topoisomerase IV A subunit	S80L	TCT->CTT	-	Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus simulans, Staphylococcus aureus	ciprofloxacin	Reslit	Supported
grlA DNA gyrase subunit A	S80R	-	DNA topoisomerase GrlA	Staphylococcus coagulans, Staphylococcus pseudintermedius, Staphylococcus intermedius	enrofloxacinfluoroquinolonesquinolones	Reference Gene CatalogReslit	Confirmed
grlA topoisomerase IV subunit A	S80Y	G240T AGT->TAT	mutations in grlA (Ser80→Phe or Tyr) were most commonly selected with trovafloxacin, ciprofloxacin, levofloxacin, or pefloxacin, Target modification	Staphylococcus aureus	fluoroquinolonesnorfloxacinciprofloxacin+6 more	ResFinder DatabaseReslit	Confirmed
grlA topoisomerase IV subunit A	S81F	-	enhances single-stranded DNA cleavage and suppresses double-stranded DNA breaks	Bacillus anthracis, Escherichia coli	fluoroquinolonesciprofloxacin	Reslit	Supported
grlA topoisomerase IV subunit A	S81P	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacinlevofloxacinmoxifloxacin	Reslit	Candidate
grlA DNA topoisomerase IV A subunit	S84L	TCT->CTT	-	Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus simulans	ciprofloxacin	Reslit	Candidate
grlA topoisomerase IV A subunit	T292I	-	-	Staphylococcus aureus	quinolones	Reslit	Candidate
grlA topoisomerase IV subunit A	T81I	-	-	Staphylococcus aureus	fluoroquinolones	Reslit	Candidate