Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
katG catalase-peroxidase | N238K | - | - | - | isoniazid | Reslit | Candidate |
| N508D | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Established | |
katG catalase-peroxidase | N596S | - | multiple resistance variants | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | Card DatabaseReslit | Confirmed |
katG KatG enzyme, a catalase-peroxidase involved in the activation of isoniazid (INH) | N655D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card DatabaseReslit | Confirmed |
| N660D | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Established | |
| P131Q | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Established | |
| P131R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Established | |
katG catalase-peroxidase | P131T | - | single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | Card DatabaseReslit | Confirmed |
katG catalase-peroxidase | P232L | - | reduced INH-KatG binding affinity | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| P232R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Established |
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