Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA penicillin-binding protein 2	A501T	-	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	cefiximeceftriaxonecefotaxime+5 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
penA penicillin-binding protein 2	A501V	-	increased resistance, reduced reactivity for β-lactams, decreased susceptibility to cefixime and ceftriaxone, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	cefiximeceftriaxonecefotaxime+4 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
penA Penicillin-Binding Protein 2	A510V	T1532C	reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxonecefiximepenicillin+3 more	Reference Gene CatalogReslit	Confirmed
penA penicillin-binding protein 2	A516G	T1549G	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae	cefiximepenicillincephalosporins+1 more	Reference Gene CatalogReslit	Confirmed
penA penicillin-binding protein 2	A517G	-	-	-	ceftriaxonecefixime	Reslit	Candidate
penA penicillin-binding protein 2	A549T	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
penA penicillin-binding protein 2	A574V	-	-	-	cefixime	Reslit	Candidate
penA penicillin-binding protein	A60G	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
penA β-lactamase	C69F	-	-	Burkholderia thailandensis	ceftazidime	Reslit	Candidate
penA β-lactamase	C69Y	-	increased resistance, altered substrate specificity	Burkholderia pseudomallei	ceftazidime	Reslit	Supported