Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ampD AmpD	V84X	-	loss of function	Enterobacter cloacae	cefoxitincefotaximecefepime+3 more	Reslit	Candidate
ampD regulatory protein involved in AmpC β-lactamase expression	W7*	G21A	-	-	cefotaximeceftazidimecefepime	Reslit	Candidate
ampD regulatory protein involved in AmpC β-lactamase expression	W95*	G285A	-	-	cefotaximeceftazidimecefepime	Reslit	Candidate
ampD AmpD	W95L	-	The Trp95Leu substitution was predicted to weaken ligand binding, likely affecting the positioning of the ligand in the active site.	Klebsiella aerogenes	ertapenemimipenemmeropenem	Reslit	Candidate
ampD cellobiohydrolase	Y127H	T381C	-	Pseudomonas aeruginosa	ceftazidime avibactamimipenem relebactam	Reslit	Candidate
ampD regulatory protein involved in AmpC β-lactamase expression	Y87*	C261A	-	-	cefotaximeceftazidimecefepime	Reslit	Candidate
ampDh3 regulator of AmpC beta-lactamase	A208V	-	-	-	imipenemmeropenem	Reslit	Candidate
ampDh3 regulator of AmpC beta-lactamase	A219T	-	nonfunctional AmpD proteins	Pseudomonas aeruginosa	imipenemmeropenemceftazidime+1 more	Reslit	Supported
ampDh3 peptidoglycan-recycling amidase	D137G	-	nonfunctional AmpD proteins	Pseudomonas aeruginosa	ceftazidime	Reslit	Candidate
ampG transmembrane protein	A129D	-	loss of function	Pseudomonas aeruginosa, Escherichia coli, Vibrio cholerae, Acinetobacter baumannii	ampicillin	Reslit	Candidate