Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA	ins346D	-	-	Neisseria gonorrhoeae	cephalosporins	ResFinder Database	Established
penA penicillin-binding protein 2	T316P	-	confers high-level resistance to expanded-spectrum cephalosporins	Neisseria gonorrhoeae	ceftizoximeceftriaxonecefixime	Reslit	Candidate
penA class A beta-lactamase	T32A	-	-	Burkholderia multivorans	ceftazidimeceftazidime avibactam	Reslit	Candidate
penA penicillin-binding protein 2	T483P	-	-	Neisseria gonorrhoeae	ceftiofurceftriaxone	Reslit	Candidate
penA penicillin-binding protein 2	T483S	-	confers high-level resistance to expanded-spectrum cephalosporins, reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	ceftizoximeceftriaxonecefixime+4 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
penA penicillin-binding protein 2	T485I	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
penA Penicillin-binding protein 2	T534A	-	-	Neisseria gonorrhoeae	cephalosporins	Reslit	Candidate
penA penicillin-binding protein 2	V279A	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
penA Penicillin-Binding Protein 2	V316P	-	reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxonecefiximeceftazidime+2 more	Reference Gene CatalogReslit	Confirmed
penA penicillin-binding protein 2	V316T	-	decreased susceptibility, reduced reactivity for β-lactams, decreased susceptibility to cefixime and ceftriaxone, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxonecefiximecephalosporins+2 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed