Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.
PMID: 112570262001
Key Findings
The study identified that the deletion of tolC and acrAB significantly increased susceptibility to various antibiotics, antiseptics, detergents, and dyes in Escherichia coli. Additionally, mdfA and emrE were found to contribute to resistance against specific compounds.
4gene entries
0mutation entries
AMR Genes
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| acrab | 1 | resistance-nodulation-cell division (RND) family efflux pump | ampicillinchloramphenicolflorfenicolcloxacillinpuromycinerythromycinmethotrexatenovobiocinciprofloxacin+23 more |
| Reslit | - |
| emrE | 1 | small multidrug resistance (SMR) family efflux pump | acriflavinethidium bromidemethyl viologen |
| Reslit | - |
| mdfA | 1 | major facilitator superfamily (MFS) efflux pump | ethidium bromidebenzalkonium chloride |
| Reslit | - |
| TolC | 1 | outer membrane factor | ampicillinchloramphenicolflorfenicolcloxacillinpuromycinerythromycinmethotrexatenovobiocinciprofloxacin+23 more |
| Reslit | - |