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In vitro activities of novel nonfluorinated quinolones PGE 9262932 and PGE 9509924 against clinical isolates of Staphylococcus aureus and Streptococcus pneumoniae with defined mutations in DNA gyrase and topoisomerase IV.

PMID: 120190712002

Key Findings

Mutations in gyrA are associated with quinolone resistance.

0gene entries

15mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	S84L	-	-	Streptococcus pneumoniae, Staphylococcus aureus	Quinolone	Reslit	-
gyrA	S81Y	-	-	Streptococcus pneumoniae, Staphylococcus aureus	Quinolone	Reslit	-
gyrA	S84K	-	-	Staphylococcus aureus, Streptococcus pneumoniae	Quinolone	Reslit	-
grlA	S80F	-	-	Staphylococcus aureus, Streptococcus pneumoniae	Quinolone	Reslit	-
gyrA	E88K	-	-	Staphylococcus aureus, Streptococcus pneumoniae	Quinolone	Reslit	-
gyrA	S81F	-	-	Staphylococcus aureus, Streptococcus pneumoniae	Quinolone	Reslit	-
parC	S79F	-	-	Staphylococcus aureus, Streptococcus pneumoniae	Quinolone	Reslit	-
parC	K137N	-	-	Streptococcus pneumoniae	Quinolone	Reslit	-