Emergence and persistence of macrolide resistance in oropharyngeal flora and elimination of nasal carriage of Staphylococcus aureus after therapy with slow-release clarithromycin: a randomized, double-blind, placebo-controlled study.

PMID: 155048392004

Key Findings

The study found that treatment with slow-release clarithromycin led to increased macrolide resistance in oropharyngeal flora, with significant rises in ermB and ermC genes in streptococci and staphylococci, respectively.

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3gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
erm(B)	1	target modification	Macrolide	Streptococcus pneumoniae Staphylococcus aureus	Reslit	-
erm(C)	1	target modification	Macrolide	Staphylococcus aureus	Reslit	-
mefae	1	macrolide efflux pump	Macrolide	Streptococcus pneumoniae

Browse Papers

Emergence and persistence of macrolide resistance in oropharyngeal flora and elimination of nasal carriage of Staphylococcus aureus after therapy with slow-release clarithromycin: a randomized, double-blind, placebo-controlled study.

AMR Genes