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Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID: 200087812010

Key Findings

mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones

0gene entries

16mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC	S79Y	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
parC	D83N	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
gyrA	A147G	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
parC	K137N	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
gyrA	S81A	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
parE	D435N	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
gyrA	S81F	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
parE	I460V	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
gyrA	S81Y	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
parE	I460N	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
parC	S79F	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
gyrA	E85K	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
parE	V461I	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
gyrA	E85A	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
gyrB	N473D	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-
gyrA	S82P	-	-	Streptococcus pneumoniae	moxifloxacin\|levofloxacin\|gemifloxacin	Reslit	-