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Key Findings
Mutations in the genes encoding LiaF and a GdpD-family protein were necessary and sufficient for the development of resistance to daptomycin in Enterococcus faecalis. Additionally, an Arg218 Gln substitution in the Cls enzyme was found in daptomycin-resistant E. faecium isolates.
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| I171del | - | three-component signaling pathway regulator LiaF | Enterococcus faecalis | DAPTOMYCIN | Reference Gene Catalog | - | |
| R218Q | - | cardiolipin synthase Cls | Enterococcus faecium | DAPTOMYCIN | Reference Gene Catalog | - | |
| N13I | - | cardiolipin synthase Cls, single resistance variant | Enterococcus faecium | DAPTOMYCIN |
Reference Gene CatalogCard Database |
| - |
| H215R | - | cardiolipin synthase Cls, single resistance variant | Enterococcus faecium | DAPTOMYCINDaptomycin | Reference Gene CatalogCard Database | - |
| I144T | - | single resistance variant | Enterococcus faecium | Daptomycin | Card Database | - |
| A180T | - | single resistance variant | Enterococcus faecium, Enterococcus faecalis | Daptomycin | Card Database | - |
| L39F | - | single resistance variant | Enterococcus faecium | Daptomycin | Card Database | - |
| W73C | - | single resistance variant | Enterococcus faecium | Daptomycin | Card Database | - |
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