High proportion of fluoroquinolone-resistant Mycobacterium tuberculosis isolates with novel gyrase polymorphisms and a gyrA region associated with fluoroquinolone susceptibility.

PMID: 221891172012

Key Findings

These mutations were identified in fluoroquinolone-resistant isolates and are associated with reduced susceptibility to fluoroquinolones.

0gene entries

4mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	Q113L	-	-	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-
gyrB	N538I	-	-	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-
gyrA	M81T	-	-	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-
gyrA	L109P	-	-	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-