Acquisition of the mcr-1 Gene Lowers the Target Mutation to Impede the Evolution of a High-Level Colistin-Resistant Mutant in Escherichia coli.

PMID: 344084482021

Key Findings

The study identifies mutations in the pmrAB, phoPQ, and mgrB genes that contribute to colistin resistance in E. coli, and shows that the presence of the mcr-1 gene reduces the likelihood of developing high-level colistin-resistant mutants.

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1gene entry

19mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mcr-1	1	plasmid-mediated colistin resistance gene	Colistin	Escherichia coli	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pmrA	S144G	-	affects protein function	E. coli	Colistin	Reslit	-
pmrB	C84Y	-	-	E. coli	Colistin	Reslit	-
phoP	H6R	-	-	E. coli	Colistin	Reslit

Browse Papers

Acquisition of the mcr-1 Gene Lowers the Target Mutation to Impede the Evolution of a High-Level Colistin-Resistant Mutant in Escherichia coli.

AMR Genes

AMR Mutations