Key Findings

The study identifies blaKPC, blaNDM, and blaIMP genes as the primary carbapenemase genes in carbapenemase-producing Klebsiella pneumoniae (cpKP) isolates in China, highlighting their association with the spread of CG258 cpKP isolates. It also characterizes specific Inc groups of blaKPC-harboring plasmids that contribute to the resistance and competitive advantage of these isolates.