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Key Findings
Mutations in the two-component regulator BaeSR (D89V in BaeS and S104N in BaeR) mediate cefiderocol resistance in Acinetobacter baumannii by up-regulating efflux pump genes, particularly MFS transporters and MacAB-TolC. Additionally, the BaeS mutation increases virulence by up-regulating the paa operon.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| baeR | 1 | two-component system sensor kinase | Cefiderocol |
| Reslit | - |
| baeS | 1 | two-component system histidine kinase | Cefiderocol |
| Reslit | - |
| macAB | 1 | efflux pump complex | Cefiderocol |
|
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| D89V | - | two-component system sensor histidine kinase BaeS, single resistance variant | Acinetobacter baumannii, Enterobacter cloacae | CEFIDEROCOL | Reference Gene CatalogCard Database | - | |
| S104N | - | envelope stress response regulator BaeR, single resistance variant | Acinetobacter baumannii, Enterobacter cloacae | CEFIDEROCOL | Reference Gene CatalogCard Database | - |
Reslit |
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