Antimicrobial susceptibility and virulence gene analysis of Shigella species causing dysentery in Iranian children: Implications for fluroquinolone resistance.

PMID: 391304112024Iran

Key Findings

The study identified qnrA, qnrS, and qnrD genes as major contributors to plasmid-mediated quinolone resistance in Shigella isolates, along with specific mutations in gyrA and parC genes associated with fluoroquinolone resistance.

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3gene entries

3mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
qnrA	1	plasmid-mediated quinolone resistance	Ciprofloxacin	Shigella sonnei Shigella flexneri	Reslit	-
qnrD	1	plasmid-mediated quinolone resistance	Ciprofloxacin	Shigella sonnei Shigella flexneri	Reslit	-
qnrS	1	plasmid-mediated quinolone resistance	Ciprofloxacin

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	D87Y	-	-	Shigella boydii, Shigella sonnei, Shigella flexneri	Nalidixic acid\|Ciprofloxacin	Reslit	-

Browse Papers

Antimicrobial susceptibility and virulence gene analysis of Shigella species causing dysentery in Iranian children: Implications for fluroquinolone resistance.

AMR Genes

AMR Mutations