Browse Papers

Explore scientific publications on antimicrobial resistance

Engineered Mycobacteriophage TM4::GeNL Rapidly Determines Bedaquiline, Pretomanid, Linezolid, Rifampicin, and Clofazimine Sensitivity in Mycobacterium tuberculosis Clinical Isolates.

PMID: 394123572025

Key Findings

Mutations in Rv0678 are associated with bedaquiline and clofazimine resistance.

0gene entries

14mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Rv0678	Q115P	A346C	-	-	Bedaquiline\|Clofazimine	Reslit	-
Rv0678	S53L	AGT->CTT	-	-	Bedaquiline\|Clofazimine	Reslit	-
Rv0678	A84V	C252T	-	-	Bedaquiline\|Clofazimine	Reslit	-
Rv0678	P48L	CCC->CTT	-	-	Bedaquiline\|Clofazimine	Reslit	-
Rv0678	R50Q	CGT->CAA	-	-	Bedaquiline\|Clofazimine	Reslit	-
Rv0678	L117M	CTT->ATG	-	-	Bedaquiline\|Clofazimine	Reslit	-
Rv0678	L40S	CTT->TCA	-	-	Bedaquiline\|Clofazimine	Reslit	-
pepQ	E177*	GAA->TGA	-	Mycobacterium tuberculosis	Bedaquiline\|Clofazimine	Reslit	-
rpoB	H445Y	GTT->TAT	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
Rv0678	W42R	T125A	-	-	Bedaquiline\|Clofazimine	Reslit	-
Rv0678	F93L	T278C	-	-	Bedaquiline\|Clofazimine	Reslit	-
Rv0678	F100L	T300C	-	-	Bedaquiline\|Clofazimine	Reslit	-
rplC	C154R	T462C	-	Mycobacterium tuberculosis	Linezolid	Reslit	-