Browse Papers

Explore scientific publications on antimicrobial resistance

Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin.

PMID: 394437982024

Key Findings

Mutations in rpoB lead to daptomycin resistance in VREfm.

0gene entries

9mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	G482D	-	upregulation of a previously uncharacterized operon (prdRAB) that leads to cell membrane remodelling and cross-resistance to daptomycin through reduced binding of the antibiotic	Enterococcus faecium	Daptomycin	Reslit	-
rpoB	H486Y	-	upregulation of a previously uncharacterized operon (prdRAB) that leads to cell membrane remodelling and cross-resistance to daptomycin through reduced binding of the antibiotic	Enterococcus faecium	Daptomycin	Reslit	-
rpoC	T634K	-	-	Enterococcus faecium	Daptomycin	Reslit	-
rpoB	S491F	-	upregulation of a previously uncharacterized operon (prdRAB) that leads to cell membrane remodelling and cross-resistance to daptomycin through reduced binding of the antibiotic	Enterococcus faecium	Daptomycin	Reslit	-
rpoB	Q473L	-	upregulation of a previously uncharacterized operon (prdRAB) that leads to cell membrane remodelling and cross-resistance to daptomycin through reduced binding of the antibiotic	Enterococcus faecium	Daptomycin	Reslit	-
rpoB	T634K	-	upregulation of a previously uncharacterized operon (prdRAB) that leads to cell membrane remodelling and cross-resistance to daptomycin through reduced binding of the antibiotic	Enterococcus faecium	Daptomycin	Reslit	-