Sequence variation in the active site of mobile colistin resistance proteins is evolutionarily accommodated through inter-domain interactions.

PMID: 395092062024

Key Findings

Wild-type MCR-1 increases the MIC of colistin by ~12-fold

2gene entries

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mcr-1	1	mobile colistin resistance protein	Colistin	E. coli K-12 BW25113	Reslit	-
mcr-5	1	mobile colistin resistance protein	Colistin	E. coli K-12 BW25113	Reslit	-

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mcr-1	S284D	-	-	E. coli	Colistin	Reslit	-