Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81.

PMID: 395926502024Europe|Tunisia

Key Findings

The study identifies qnrB, qnrS, aac(6')-Ib-cr, and the novel allele qnrB81 as plasmid-mediated quinolone resistance genes in E. coli isolates. Mutations in the QRDRs of gyrA and parC contribute to fluoroquinolone resistance.

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7gene entries

19mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
aac(6')-Ib-cr	1	aminoglycoside acetyltransferase	-	Escherichia coli	Reslit	-
qnrB	3	plasmid-mediated quinolone resistance protein	Fluoroquinolone	Escherichia coli	Reslit	-
qnrS	3	plasmid-mediated quinolone resistance protein	Fluoroquinolone	Escherichia coli	Reslit

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC	E84K	GAG -> AAA	-	E. coli	Fluoroquinolones	Reslit	-
gyrA	S83Y	TCA -> TAT	-	E. coli	Fluoroquinolones	Reslit	-
parC	E84V	A253T	-

Browse Papers

Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81.

AMR Genes

AMR Mutations