Identification of genetic determinants of antibiotic resistance in Helicobacter pylori isolates in Vietnam by high-throughput sequencing.

PMID: 403123242025Vietnam

Key Findings

The study identified several mutations in 23S rRNA, gyrA, pbp1 A, and rdxA genes associated with resistance to clarithromycin, levofloxacin, amoxicillin, and metronidazole in H. pylori isolates from Vietnam.

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2gene entries

3mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
pbp1a	1	penicillin-binding protein 1A	Amoxicillin	Helicobacter pylori	Reslit	-
rdxA	1	nitroreductase	Metronidazole	Helicobacter pylori	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	D91Y	-	confer resistance to LVX	Helicobacter pylori	Levofloxacin	Reslit	-
rdxA	G163D	-	-	-	Metronidazole	Reslit	-
rdxA	G163S	-	-	-	Metronidazole	Reslit	-

Browse Papers

Identification of genetic determinants of antibiotic resistance in Helicobacter pylori isolates in Vietnam by high-throughput sequencing.

AMR Genes

AMR Mutations