Burkholderia pseudomallei PenI beta-lactamase and variants are potently inhibited by taniborbactam.

PMID: 409383512025

Key Findings

Taniborbactam effectively inhibits the beta-lactamase PenI and its variants C69Y and P167S, reducing the MIC of cefepime in E. coli strains expressing these enzymes.

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2gene entries

4mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaPEN-I	1	beta-lactamase	CeftazidimeCefepime	Escherichia coli Burkholderia pseudomallei	Reslit	-
penA	1	penicillin-binding protein	Ceftazidime	Burkholderia pseudomallei	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaPenI	P167S	-	-	Burkholderia pseudomallei, Escherichia coli	Ceftazidime	Reslit	-
blaPenI	C69Y	-	-	Escherichia coli, Burkholderia pseudomallei	Ceftazidime	Reslit	-

Browse Papers

Burkholderia pseudomallei PenI beta-lactamase and variants are potently inhibited by taniborbactam.

AMR Genes

AMR Mutations