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Off-label evaluation of the BD MAX MDR-TB assay for rapid diagnosis of rifampicin and isoniazid resistance of Mycobacterium tuberculosis clinical isolates in a high-volume reference laboratory.

PMID: 409857442025

Key Findings

Mutations in katG confer resistance to isoniazid

0gene entries

24mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
katG	S315R	-	-	-	Isoniazid	Reslit	-
rpoB	D435V	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	D435E	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
katG	S315T	-	-	-	Isoniazid	Reslit	-
rpoB	L430P	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	S450L	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	L430R	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	S450W	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	Q432H	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	F433F	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	L452P	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	H445L	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	T427T	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	F424L	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	D435F	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	T427A	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	L452Q	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
inhA	-	T-8G	-	Mycobacterium tuberculosis	Isoniazid	Reslit	-