Unraveling Epistatic Interactions Between Sites Under Drug-Dependent Selection in the Mycobacterium tuberculosis Genome.

PMID: 410991382025

Key Findings

Mutation rpoB:S450L is associated with RIF resistance

3gene entries

4mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
eis	1	eis	AMKKAN	Mycobacterium tuberculosis	Reslit	-
gid	1	gid	Streptomycin	Mycobacterium tuberculosis	Reslit	-
rrs	1	rrs	StreptomycinAMKCAPKAN	Mycobacterium tuberculosis	Reslit	-

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	S450L	-	-	Mycobacterium tuberculosis	RIF	Reslit	-
embB	M306V	-	-	-	EMB	Reslit	-
katG	S315T	-	-	Mycobacterium tuberculosis	INH	Reslit	-