Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pncA	W68L	-	reduce the binding affinity of pyrazinamide (PZA) to the enzyme, disrupts substrate binding and catalytic activity, single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA pyrazinamidase	W68R	T202C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA	W68S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA pyrazinamidase/nicotinamidase	Y10*	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
pncA pyrazinamidase	Y103*	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA pyrazinamidase	Y103C	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA pyrazinamidase/nicotinamidase	Y103D	T309G	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA	Y103H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA	Y103S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA	Y34*	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established