Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ponA penicillin-binding protein 1	A375T	-	-	Neisseria gonorrhoeae	penicillin	Reslit	Candidate
ponA penicillin-binding protein 1	L421P	C1262T	increased MIC, decreases penicillin acylation of PBP1 and increases penicillin resistance, reduces penicillin acylation of PBP1 ~3- to 4-fold, penicillin-binding protein 1 PonA	Neisseria gonorrhoeae	cefiximeceftriaxonepenicillin+4 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
ponA1	Q365H	-	single resistance variant	Mycobacterium tuberculosis	rifabutin	Card Database	Established
ponA1	T658A	-	single resistance variant	Mycobacterium tuberculosis	rifabutin	Card Database	Established
ponA2 PBP1b	T188A	-	-	Mycobacterium tuberculosis	amoxicillinmeropenem	Reslit	Candidate
porA outer membrane protein	-	A-5T	-	Campylobacter coli	-	Reslit	Candidate
porA outer membrane porin	D142H	-	loss of calcium-binding site in channel	Campylobacter jejuni	ciprofloxacin	Reslit	Candidate
porA major outer membrane protein (MOMP)	G56D	-	Efflux, group 2 major outer membrane porin protein PorA	Campylobacter jejuni	ertapenemmeropenemcarbapenems	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
porA	ins139D	-	Efflux	Campylobacter jejuni	ertapenemmeropenem	ResFinder Database	Established
porA	N138ND	-	group 2 major outer membrane porin protein PorA	Campylobacter jejuni	carbapenems	Reference Gene Catalog	Established