Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
tonB periplasmic membrane protein	-	9fs	-	Stenotrophomonas maltophilia	cephalosporinscarbapenems	Reslit	Candidate
topA topoisomerase I	S180L	-	reduces its activity	Escherichia coli	kanamycin	Reslit	Candidate
toprJ1 efflux pump component	Q40R	-	-	Klebsiella pneumoniae	tigecycline	Reslit	Candidate
tpr	-	A2059G	-	Treponema pallidum	azithromycin	Reslit	Candidate
tpr putative tetratricopeptide (TPR) repeat-containing transport protein gene	M439I	-	-	Clostridium difficile	linezolid	Reslit	Candidate
traJ TraJ protein	-	A51G	-	Escherichia coli	colistin	Reslit	Candidate
triC inner membrane RND transporter	G598V	-	reduction of Nile Red efflux by TriABC and obliterated the TriABC-dependent resistance to SDS and triclosan	Pseudomonas aeruginosa	triclosan	Reslit	Candidate
triC inner membrane RND transporter	Q181A	-	more than 8-fold decrease in the MIC (minimal inhibitory concentration) of triclosan, a decrease in the ability to expel Nile Red, and a concurrent the loss of protection against SDS	Pseudomonas aeruginosa	triclosan	Reslit	Candidate
triC inner membrane RND transporter	R603A	-	partial loss in the ability to confer triclosan resistance (2 to 4 fold MIC decrease in comparison to WT) and was matched by a partial loss of Nile Red efflux	Pseudomonas aeruginosa	triclosan	Reslit	Candidate
triC inner membrane RND transporter	S276A	-	active in efflux of Nile Red and displayed resistance to triclosan but could only partially complement the SDS susceptibility of efflux-deficient Δ9 cells	Pseudomonas aeruginosa	triclosan	Reslit	Candidate