Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
vanC2 d-alanyl-d-serine ligase	F250Y	-	The F250Y mutation decreases the use of D-serine and broadens the specificity for other D-amino acids.	Enterococcus casseliflavus, Escherichia coli	vancomycin	Reslit	Candidate
vanC2 d-alanyl-d-serine ligase	L282R	-	The L282R mutation increases the preference for D-serine over D-alanine.	Enterococcus casseliflavus, Escherichia coli	vancomycin	Reslit	Candidate
vanC2 d-alanyl-d-serine ligase	R322M	-	The R322M mutation decreases the use of D-serine and broadens the specificity for other D-amino acids.	Enterococcus casseliflavus, Escherichia coli	vancomycin	Reslit	Candidate
vanE ligase that synthesizes the dipeptide d-Ala-d-Ser	D200N	-	-	Enterococcus faecalis	glycopeptides	Reslit	Candidate
vanR response regulator of the OmpR/PhoB family	M55I	G167T	constitutive expression of the vanG operon	Clostridioides difficile	vancomycin	Reslit	Candidate
vanR transcriptional regulator	P216T	-	-	Staphylococcus aureus	vancomycin	Reslit	Candidate
vanR	T115A	-	likely affects the expression of the downstream resistance genes	Clostridioides difficile	vancomycin	Reslit	Supported
vanR response regulator	T69S	-	allows activation independent of VanS	Streptomyces toyocaensis, Streptomyces coelicolor	glycopeptides	Reslit	Candidate
vanRE	Y225F	-	-	Enterococcus faecalis	glycopeptides	Reslit	Candidate
vanS-Cd	G339D	-	VanG-Cd-type vancomycin resistance histidine kinase VanS	Clostridioides difficile	vancomycin	Reference Gene Catalog	Established