Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase subunit A	S81N	-	-	Streptococcus agalactiae	norfloxacin	Reslit	Candidate
gyrA DNA gyrase subunit	S81V	-	-	Streptococcus pneumoniae	fluoroquinolones	Reslit	Candidate
gyrA DNA gyrase subunit A	S81Y	T243A	-	Streptococcus pneumoniae, Staphylococcus aureus, Streptococcus agalactiae	clinafloxacinciprofloxacintrovafloxacin+9 more	Reslit	Supported
gyrA DNA gyrase subunit A	S826T	-	-	-	fluoroquinolones	Reslit	Candidate
gyrA DNA gyrase subunit A	S82F	-	-	Bacteroides	ampicillinfluoroquinolones	Reslit	Candidate
gyrA DNA gyrase A subunit	S82L	-	-	Bacteroides fragilis	ciprofloxacinlevofloxacinmoxifloxacin+1 more	Reslit	Candidate
gyrA DNA gyrase subunit A	S82P	-	-	Streptococcus pneumoniae	moxifloxacinlevofloxacingemifloxacin	Reslit	Candidate
gyrA DNA gyrase A protein	S83A	G248A AGC->GCC	reduced fluoroquinolone susceptibility, Target modification, DNA gyrase subunit A GyrA	Escherichia coli, Nocardia cyriacigeorgica, Nocardia abscessus, Flavobacterium oreochromis, Flavobacterium covae, Flavobacterium davisii, N. cyriacigeorgica, Salmonella enterica, Klebsiella pneumoniae	ciprofloxacinfluoroquinolonesnalidixic acid+8 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	S83E	-	-	-	ciprofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	S83F	TCA->TTC TCA -> TTC AGT->TTT C249T C248T G248T TCC->TTC T249C	mutations in QRDR region, confers resistance, reduced ciprofloxacin binding affinity, mutations in gyrA confer resistance to ciprofloxacin, alter the characteristics of the binding pocket resulting in the loss of crucial molecular interactions and consequently decrease the binding affinity of fluoroquinolones with the target protein, reduced susceptibility to fluoroquinolones, alterations in gyrase, resistance to ciprofloxacin, mutations in gyrA confer resistance to quinolones and fluoroquinolones, harbored mutations gyrA (S83F), gyrA (D87Y), and parC (S80I) associated with resistance to quinolones, likely responsible for the acquired resistance to fluoroquinolones, Target modification, single resistance variant, DNA gyrase subunit A GyrA	Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes, Salmonella enterica, Yersinia pestis, Salmonella, Salmonella Typhi, Salmonella Choleraesuis, Salmonella Virchow, Salmonella Typhimurium, Glaesserella parasuis, Streptococcus pneumoniae, Haemophilus influenzae, Proteus mirabilis, Escherichia coli, Salmonella Kentucky, Salmonella typhimurium, Francisella tularensis, Salmonella typhi, Mannheimia haemolytica, Flavobacterium oreochromis, Flavobacterium covae, Flavobacterium davisii, Salmonella Enteritidis, Salmonella Paratyphi, Salmonella Heidelberg, Yersinia enterocolitica, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Acinetobacter pittii, Salmonella Dublin, Mycoplasma bovis, Salmonella 4,[5],12:i:-, Shigella sonnei, Salmonella Gallinarum, Salmonella Isangi, Gallibacterium anatis, Salmonella pullorum, Vibrio parahaemolyticus	ciprofloxacinnalidixic acidlevofloxacin+18 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed