Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase A subunit	S83I	GAT->ATT TCA->ATA G249T G248T G248A	confers resistance, associated with ciprofloxacin resistance, mutations in gyrA confer resistance to quinolones and fluoroquinolones, resistance, associated with fluoroquinolone resistance, Target modification, single resistance variant, DNA gyrase subunit A GyrA	Vibrio parahaemolyticus, Klebsiella pneumoniae, Enterobacter aerogenes, Vibrio cholerae, Aeromonas caviae, Vibrio vulnificus, Aeromonas spp., E. coli, Aeromonas salmonicida, Proteus mirabilis, Salmonella Typhi, Salmonella Typhimurium, Elizabethkingia anophelis, Riemerella anatipestifer, Escherichia coli, Enterococcus faecalis, Serratia marcescens, Campylobacter jejuni, A. hydrophila, A. sobria, Vibrio fluvialis, Mycoplasma gallisepticum, Delftia sp., Salmonella enterica, Chlamydia trachomatis, Elizabethkingia meningoseptica, Elizabethkingia miricola, Pseudomonas aeruginosa, Histophilus somni, Klebsiella oxytoca, Aeromonas hydrophila, Aeromonas veronii, Aeromonas sobria, Aeromonas dhakensis, Aeromonas jandaei, Aeromonas trota, Aeromonas media, Serratia symbiotica, Pseudomonas putida, Mycoplasma genitalium, Yersinia enterocolitica, Providencia rettgeri, Providencia stuartii, Enterococcus faecium, Enterobacter cloacae	ciprofloxacinnorfloxacinsparfloxacin+12 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit	S83L	TCA->CTA G249A AGC->CTC GCT->TTT AGT->CTT G249T G248T GAT->TTA G250T TCT->CTT TCA -> TTG TCA -> CTA GGA->TTA GAG->CTG TCC->CTC C250T GCA->CTA C248T GCA->TTA TCA->TTA C249T T248C GGA->CTA GCT->CTT TCT -> TTG GCT->TTA	mutations in gyrA confer resistance to fluoroquinolones, likely ascribed to the previously characterized mutation occurring in the gyrA gene, with a substitution of Ser for Leu at position 83 of its amino acid sequence, resistance, mutations in gyrA were associated with fluoroquinolone resistance, mutations in GyrA lead to resistance, mutated topoisomerase, reduced affinity of the drug for their targets, confers quinolone resistance, mutations in gyrase and topoisomerase IV confer resistance to fluoroquinolones, decreased affinity for ciprofloxacin, confers resistance to fluoroquinolones, deleterious, mutations in gyrase and topoisomerase genes, Target modification, single resistance variant, multiple resistance variants, DNA gyrase subunit A GyrA	Escherichia coli, non-typhoidal Salmonella, Pseudomonas aeruginosa, Acinetobacter baumannii, Orientia tsutsugamushi, Staphylococcus aureus, Neisseria gonorrhoeae, Klebsiella pneumoniae, Shigella sonnei, E. coli, Shigella flexneri, Salmonella enterica, Salmonella Typhimurium, Salmonella Hadar, Salmonella Paratyphi, Salmonella Saintpaul, Mycoplasma hominis, Haemophilus influenzae, Corynebacterium macginleyi, Salmonella paratyphi, Klebsiella spp., Salmonella Typhi, Serratia marcescens, Salmonella typhi, N. wallacei, Salmonella, Escherichia spp., Enterobacter spp., Salmonella spp., Shigella dysenteriae, Citrobacter freundii, Enterobacter cloacae, Proteus mirabilis, Vibrio cholerae, Y. pestis, Streptococcus pneumoniae, Shigella spp., Campylobacter, Neisseria meningitidis, Acinetobacter baylyi, Escherichia albertii, Brevundimonas brasiliensis, Salmonella Infantis, Kocuria polaris, Shigella boydii, Pseudomonas spp., Staphylococcus pseudintermedius, Enterococcus faecalis, Enterococcus faecium, Bacillus anthracis	ciprofloxacinofloxacinnalidixic acid+18 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA	S83N	-	Target modification, DNA gyrase subunit A GyrA	Enterococcus faecalis, Enterococcus faecium	nalidixic acidciprofloxacinquinolones	Reference Gene CatalogResFinder Database	Confirmed
gyrA DNA gyrase subunit A	S83P	-	-	Salmonella Typhi	ciprofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	S83Q	-	-	Escherichia coli	ciprofloxacinmoxifloxacinenrofloxacin+3 more	Reslit	Candidate
gyrA DNA gyrase subunit A	S83R	C250A TCA->AGA C250G	Target modification, DNA gyrase subunit A GyrA	Enterococcus faecium, Yersinia enterocolitica, Mycoplasma gallisepticum, Chlamydia trachomatis, Enterococcus faecalis, Riemerella anatipestifer, Serratia marcescens, Elizabethkingia anophelis, Elizabethkingia meningoseptica, Vibrio vulnificus	ciprofloxacinfluoroquinolonesnalidixic acid+7 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	S83T	TCA -> ACC G249C	reduced susceptibility to quinolone as a result of the diminished binding of quinolones to the topoisomerase-DNA complex, DNA gyrase subunit A GyrA	E. coli, N. otitidiscaviarum, N. terpenica, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, Klebsiella oxytoca, Serratia symbiotica	fluoroquinolonesciprofloxacinlevofloxacin+2 more	Reference Gene CatalogReslit	Confirmed
gyrA DNA gyrase subunit A	S83V	AGT->GTG	Target modification, DNA gyrase subunit A GyrA	Flavobacterium oreochromis, Flavobacterium covae, Flavobacterium davisii, N. sp, Chryseobacterium indologenes, Enterococcus cecorum, Escherichia coli	oxolinic acidenrofloxacinfluoroquinolones+5 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase A protein	S83W	GCT->TGG TCA -> TGG	Target modification, single resistance variant, DNA gyrase subunit A GyrA	Escherichia coli, E. coli, N. wallacei	nalidixic acidfluoroquinolonesciprofloxacin+1 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	S83Y	G248T TCA->TAC TCA -> TAT AGT->TAT TCT->TAC TCA->TAT TCC->TAC C248A T249A	reduced susceptibility to ciprofloxacin, mutations in QRDR region, confers resistance, mutations in gyrA ... confer resistance to ciprofloxacin, reduced ciprofloxacin binding affinity, alter the characteristics of the binding pocket resulting in the loss of crucial molecular interactions and consequently decrease the binding affinity of fluoroquinolones with the target protein, reduced susceptibility to fluoroquinolones, alterations in gyrase, reduced susceptibility, mutations in gyrA confer resistance to ciprofloxacin, Target modification, DNA gyrase subunit A GyrA	Klebsiella pneumoniae, Enterobacter aerogenes, Salmonella enterica, Salmonella Typhi, Salmonella Typhimurium, E. coli, Glaesserella parasuis, Salmonella, Escherichia coli, Salmonella Enteritidis, Salmonella typhi, Mannheimia haemolytica, Escherichia spp., Enterobacter spp., Klebsiella spp., Salmonella spp., Chryseobacterium indologenes, Salmonella Dublin, Salmonella 4,[5],12:i:-, Enterococcus cecorum, Salmonella Derby, Gallibacterium anatis, Salmonella Paratyphi, Salmonella typhimurium, Enterococcus faecalis, Enterococcus faecium, Enterobacter cloacae	ciprofloxacinnalidixic acidofloxacin+10 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed